CD274 Antilichaam (10F.9G2] (PE)

The 10F.9G2 monoclonal antibody specifically reacts with mouse CD274, also known as B7-H1 or PD-L1, a 43 kDa glycoprotein of the B7 family of the immunoglobulin superfamily. CD274 is expressed on the B and T lymphocytes, natural killer cells, and dendritic cells. The receptor for the B7-H1 molecule is PD-1, which contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM), and is expressed on activated B and T cells. The interaction between CD274 and PD-1 seems to downregulate the T and B immune responses.

29126

Q9NZQ7

Mouse

10F.9G2

PE

Primary Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Rat IgG2b, kappa

The 10F.9G2 monoclonal antibody specifically reacts with mouse CD274, also known as B7-H1 or PD-L1, a 43 kDa glycoprotein of the B7 family of the immunoglobulin superfamily.

CD274

CD274 molecule

Homo sapiens

Akashi, S., Ogata, H., Kirikae, F., Kirikae, T., Kawasaki, K., Nishijima, M., ... Miyake, K. (2000) . Regulatory roles for CD14 and phosphatidylinositol in the signaling via toll-like receptor 4-MD-2.Biochemical and biophysical research communications,268 (1), 172-177.

Shimazu, R., Akashi, S., Ogata, H., Nagai, Y., Fukudome, K., Miyake, K., Kimoto, M. (1999) . MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4.The Journal of experimental medicine,189 (11), 1777-1782.

Mirlashari, M. R., Lyberg, T. (2003) . Expression and involvement of Toll-like receptors (TLR) 2, TLR4, and CD14 in monocyte TNF-alpha production induced by lipopolysaccharides from Neisseria meningitidis.Medical science monitor: international medical journal of experimental and clinical research,9 (8), BR316-24.

B7-H, B7H1, PDL1, PD-L1, PDCD1L1, PDCD1LG1, CD274

Flow

Liquid