CD279 Antilichaam [J43.1]

The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1), a 50-55 kDa glycoprotein of the Ig superfamily. The PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-H2) are members of the B7 family. Pd-1 contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) and influences the peripheral tolerances and autoimmune diseases in mice. PD-1 is transiently expressed on CD4/CD8 thymocytes, it is upregulated in apoptotic cells, and it is expressed by activated myeloid and T and B cells. The binding of PD-1 to its ligands is blocked by the J43 antibody, which also enhances contact hypersensitivity and exacerbates acute Graft-versus-host disease, Experimental autoimmune encephalomyelitis and NOD diabetes. PD-1 seems to downregulate the immune response, as the development of splenomegaly and breakdown of peripheral tolerance in PD-1 deficient mice suggests.

18566

Q02242

Mouse

J43.1

Unconjugated

Primary Antibodies, Functional Antibodies

Immunology, Apoptosis

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Armenian Hamster IgG

The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1), a 50-55 kDa glycoprotein of the Ig superfamily.

Pdcd1

Programmed cell death 1

Mus musculus

Nishimura, H., Agata, Y., Kawasaki, A., Sato, M., Imamura, S., Minato, N., ... Honjo, T. (1996) . Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4CD8) thymocytes.International immunology,8 (5), 773-780.

Salama, A. D., Chitnis, T., Imitola, J., Ansari, M. J. I., Akiba, H., Tushima, F., ... Khoury, S. J. (2003) . Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis.The Journal of experimental medicine,198 (1), 71-78.

Carreno, B. M., Collins, M. (2002) . The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses.Annual review of immunology,20 (1), 29-53.

PD-1, Pdc1, Ly101, Pdcd1

Flow, IHC, IP

Liquid