CD28 Antilichaam [CD28.2] (APC)

The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes. CD28 is a ligand for B7-1 (CD80) and B7-2 (CD86), a co-stimulator of T lymphocytes, and enhances the interaction between T and B lymphocytes. It has been reported that the T lymphocytes stimulation to produce IL-2 depends on the monoclonal antibody involved, which suggests that the CD28 molecule presents some subregions with distinct functions. The CD28.2 antibody induces Ca2+ influx in Jurkat T lymphocytes. Other studies have shown that CD28 is involved in the signal transduction.

920

P10747

Human

CD28.2

APC

Primary Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Mouse IgG1, kappa

The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes.

CD28

CD28 molecule

Homo sapiens

Nandi, D., Gross, J. A., Allison, J. P. (1994) . CD28-mediated costimulation is necessary for optimal proliferation of murine NK cells.The Journal of Immunology,152 (7), 3361-3369.

Gross, J. A., Callas, E. L. E. N. I., Allison, J. P. (1992) . Identification and distribution of the costimulatory receptor CD28 in the mouse.The Journal of Immunology,149 (2), 380-388.

Grossi, J. A., Raulet, D. H., Allison, J. P. (1992) . CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones.Nature,356, 607-9.

Nishio, M., Spielman, J., Lee, R. K., Nelson, D. L., Podack, E. R. (1996) . CD80 (B7. 1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis.The Journal of Immunology,157 (10), 4347-4353.

Tp44, CD28

Flow

Liquid