CD284 Antilichaam (TA125] (PE)

The HTA125 monoclonal antibody specifically reacts with human CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4) . CD284 is an important molecule in the innate immunity response to bacterial lipoproteins. It is expressed by monocytes, macrophages, and endothelial cells. The HTA125 antibody can block Lipopolysaccharide-induced cytokine production and immunoprecipitate human TLR4.

7099

O00206

Human

HTA125

PE

Primary Antibodies

Innate Immunity

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Mouse IgG2a, kappa

The HTA125 monoclonal antibody specifically reacts with human CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4) .

TLR4

Toll-like receptor 4

Homo sapiens

Yang, D., Liu, Y., Chen, Y., Jiao, D., Hou, X., Wang, L., Fu, N. (2012) . Pretreatment with Mycobacterium avium-derived lipids attenuates the response of murine macrophages to components of Mycobacterium tuberculosis.International journal of molecular medicine,29 (6), 1072.

Nomura, F., Akashi, S., Sakao, Y., Sato, S., Kawai, T., Matsumoto, M., ... Akira, S. (2000) . Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression.The Journal of Immunology,164 (7), 3476-3479.

Sato, S., Nomura, F., Kawai, T., Takeuchi, O., Mhlradt, P. F., Takeda, K., Akira, S. (2000) . Synergy and cross-tolerance between toll-like receptor (TLR) 2-and TLR4-mediated signaling pathways.The Journal of Immunology,165 (12), 7096-7101.

TOLL, CD284, TLR-4, ARMD10, TLR4

Flow

Liquid