CD3 Antilichaam [17A2] (Violet-450)

The 17A2 monoclonal antibody specifically reacts with the mouse T lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation. CD3 is expressed by thymocytes and mature lymphocytes, and contains gamma, delta, and epsilon subunits, involved in the assembly, trafficking, and surface expression of T-cell receptor complex. The interaction between the T lymphocytes and the 17A2 antibody can be blocked by the 145-2C11 anti-CD3e antibody, demonstrating that the 17A2 antibody recognizes the CD3 epsilon chain.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.

12501

P22646

Mouse

17A2

Violet-450

Primary Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Rat IgG2b, kappa

The 17A2 monoclonal antibody specifically reacts with the mouse T lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation.

Cd3e

CD3 antigen, epsilon polypeptide

Mus musculus

Miescher, G. C., Schreyer, M., MacDonald, H. R. (1989) . Production and characterization of a rat monoclonal antibody against the murine CD3 molecular complex.Immunology letters,23 (2), 113-118.

Mysliwietz, J., Thierfelder, S. (1992) . Antilymphocytic antibodies and marrow transplantation. XII. Suppression of graft-versus-host disease by T-cell-modulating and depleting antimouse CD3 antibody is most effective when preinjected in the marrow recipient.Blood,80 (10), 2661-2667.

Wu, L., Antica, M., Johnson, G. R., Scollay, R., Shortman, K. (1991) . Developmental potential of the earliest precursor cells from the adult mouse thymus.The Journal of experimental medicine,174 (6), 1617-1627.

CD3, T3e, AI504783, CD3epsilon, Cd3e

Flow

Liquid