CD3 epsilon Recombinant antilichaam [145-2c11] (OAAV00070)

CD3 antigen, epsilon polypeptide

AI504783; CD3; CD3epsilon; T3e; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain.

12501

P22646

NP_031674.1

Mouse

H-2Kb-specific murine cytotoxic T-lymphocyte (CTL) clone.

145-2C11

Recombinant Monoclonal Antibody

Purified

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell developement (PubMed:19956738, PubMed:24899501) . Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.

PBS with 0.02% Proclin 300.

Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.

IgG, kappa

Recognises a 25-kDa protein component (CD3e, originally called T3-e) of the antigen-specific T-cell receptor.

Cd3e

Hamster

T-cell surface glycoprotein CD3 epsilon chain

Cd3e

NM_007648.4