CD3 epsilon Recombinant antilichaam [ucht1] (OAAV00074)

CD3e molecule

CD3e antigen, epsilon polypeptide (TiT3 complex) ; CD3e molecule, epsilon (CD3-TCR complex) ; CD3-epsilon; IMD18; T3E; T-cell antigen receptor complex, epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; TCRE.

916

P07766

NP_000724.1

Human

Human infant thymocytes.

UCHT1

Recombinant Monoclonal Antibody

Purified

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098) . In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell developement. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128) .

PBS with 0.02% Proclin 300.

Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.

IgG1, kappa

Epitopes on CD3-ε found in heterodimers with CD3-δ and with CD3-γ of a/β T cell receptor (TCR) .

CD3E

Mouse

T-cell surface glycoprotein CD3 epsilon chain

CD3E

NM_000733.3