CD32-antilichaam [4] (APC)

The 6C4 monoclonal antibody specifically recognizes two isoforms of human CD32, Fc gamma RIIA and Fc gamma RIIB. From alternative mRNA splicing, 6 isoforms of CD32 have been reported. CD32 is a 40 kDA polymorphic transmembrane glycoprotein expressed on monocytes, macrophages, graulocytes, B cells, and platelets. The receptor has low affinity toward IgG and is involved in immunomodulation, phagocytosis, and the inflammation response. The 6C4 antibody in a rosette blocking assay is reported to inhibit Ig binding

2212

P12318

Human

6C4

APC

Primary Antibodies

Innate Immunity

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Mouse IgG1, kappa

The 6C4 monoclonal antibody specifically recognizes two isoforms of human CD32, Fc gamma RIIA and Fc gamma RIIB.

FCGR2A

Fc fragment of IgG, low affinity IIa, receptor (CD32)

Homo sapiens

VELY, F., GRUEL, N., MONCUIT, J., COCHET, O., ROUARD, H., DARE, S., ... TEILLAUD, J. L. (1997) . A new set of monoclonal antibodies against human Fc-gamma RII (CD32) and Fc-gamma RIII (CD16) : characterization and use in various assays.Hybridoma,16 (6), 519-528.

Liebert, M. A. (1997) . 6C4, 2B2, 3D3.Hybridoma,16 (6) .

Bouhlal, H., Martinvalet, D., Teillaud, J. L., Fridman, C., Kazatchkine, M. D., Bayry, J., ... Kaveri, S. V. (2014) . Natural Autoantibodies to Fc-gamma Receptors in Intravenous Immunoglobulins.Journal of clinical immunology, 1-8.

CD32, FCG2, FcGR, CD32A, CDw32, FCGR2, IGFR2, FCGR2A1, FCGR2A

Flow

Liquid