CD32 (fosfo Tyr292) Antilichaam

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

2213

P31994

NP_003992.3

Human

CD32 (phospho Tyr292) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 292 (I-T-Y (p) -S-L) derived from Human CD32.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

32 kDa

IgG

The antibody detects endogenous levels of CD32 only when phosphorylated at tyrosine 292.

Western Blot: 1:500~1:1000

FCGR2B

Fc fragment of IgG, low affinity IIb, receptor (CD32)

Homo sapiens

Stuart S.G., EMBO J. 8:3657-3666 (1989) .

Brooks D.G., J. Exp. Med. 170:1369-1385 (1989) .

Engelhardt W., Eur. J. Immunol. 20:1367-1377 (1990) .

CD32, FCG2, FCG2B, , LY-17, CDW32

WB

50511930

Liquid