CD35 (CR1) Mouse Monoclonal Antibody [Kloon ID: LBI2A8]

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]

Carrier-free (BSA/glycerol-free) CR1 mouse monoclonal antibody, clone LBI2A8

C3BR; C4BR; CD35; KN

Homo sapiens complement C3b/C4b receptor 1 (Knops blood group) (CR1), transcript variant F, mRNA.

1378

P17927

Unconjugated

Complement and coagulation cascades, Hematopoietic cell lineage

Complement and coagulation cascades, Hematopoietic cell lineage

WB 1:2000, IHC 1:500

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, Transmembrane

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

CR1

https://www.ncbi.nlm.nih.gov/gene/?term=1378

https://www.uniprot.org/uniprot/P17927