CD38 Antilichaam [NIMR-5]

Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR) and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR) . It is expressed at high levels on the surface of peripheral B-lineage cells and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCRalphabeta+, CD4-, CD8-. Murine CD38 is also expressed by all Mac-1+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone-marrow-derived macrophages. Monoclonal antibodies to CD38 have been shown to induce B and T cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis.

12494

P56528

P56528

Mouse

BCL1 plasma membrane glycoproteins

[NIMR-5]

Unconjugated

Primary Antibodies

Cancer, Immunology, Obesity, Signal Transduction

0.5 mg/mL

Supplied in PBS

None

Dry Ice

Store vial at -20˚ C

IgG2a

CD38

CD38 Antibody [NIMR-5] for use in flow cytometry, immunohistochemistry, immunoprecipitation, activation, stimulation, and blocking assays.

Cd38

CD38 antigen

Mus musculus

T10, ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase

Flow

Liquid