CD3e Antilichaam [145-2C11]

The 145-2C11 monoclonal antibody reacts with mouse CD3e, the 20 kDa epsilon chain of the TCR complex. Together with the gamma and delta subunits of CD3, the epsilon subunits are involved in the assembly, trafficking, and surface expression of T-cell receptor complex. CD3 is expressed on thymocytes, mature T cells, and natural killer T cells, and the epsilon chain enhances the antigen recognition.The 145-2C11 antibody binds to the TCR complex and, depending on the conditions, initiates T cells activation, proliferation, and apoptosis. The soluble antibody seems to block lysis of target cells by antigen-specific cytotoxic T lymphocytes. The 145-2C11 antibody does not cross-react with the rat leukocytes, and it is used as a phenotypic marker for mouse T lymphocytes.

12501

P22646

Mouse

145-2C11

Unconjugated

Primary Antibodies, Functional Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Armenian Hamster IgG

The 145-2C11 monoclonal antibody reacts with mouse CD3e, the 20 kDa epsilon chain of the TCR complex.

Cd3e

CD3 antigen, epsilon polypeptide

Mus musculus

Leo, O., Foo, M., Sachs, D. H., Samelson, L. E., Bluestone, J. A. (1987) . Identification of a monoclonal antibody specific for a murine T3 polypeptide.Proceedings of the National Academy of Sciences,84 (5), 1374-1378.

Nakano, H., Yamazaki, T., Miyatake, S., Nozaki, N., Kikuchi, A., Saito, T. (1996) . Specific Interaction of Topoisomerase II and the CD3 Chain of the T Cell Receptor Complex.Journal of Biological Chemistry,271 (11), 6483-6489.

Salmond, R. J., Filby, A., Pirinen, N., Magee, A. I., Zamoyska, R. (2011) . Mislocalization of Lck impairs thymocyte differentiation and can promote development of thymomas.Blood,117 (1), 108-117.

CD3, T3e, AI504783, CD3epsilon, Cd3e

Flow, Functional Assays, IHC, IF, IP, WB

Liquid