CD3e Antilichaam [145-2C11]

CD3epsilon, a member of the immunoglobulin superfamily of cell surface receptors, is comprised of five invariable chains ranging in size from 16-28 kDa and is closely associated with the T cell antigen receptor (TCR) . It is expressed on all T cells of all mouse strains. CD3 plays a major role in signaling during antigen recognition, leading to T-cell activation. The 145-2C11 monoclonal antibody recognizes an epitope on the 25 kDa epsilon chain of the CD3/TCR complex. In the presence of Fc receptor-bearing accessory cells, soluble 145-2C11 can activate primed and naïve T cell in vitro. 145-2C11 can also induce redirected lysis of specific target cells by CTL clones and it can block lysis of specific target cells by antigen-specific CTL’s. Immobilized 145-2C11 can activate both normal T lymphocytes and cloned T cell lines. Under certain conditions, T cell activation by 145-2C11 may result in apoptotic cell death.

12501

P22646

P22646

Mouse

H-2Kb-specific murine cytotoxic T-lymphocyte (CTL) clone BM10-37

[145-2C11]

Unconjugated

Primary Antibodies

Immunology

0.5 mg/mL

Supplied in PBS

None

Dry Ice

Store vial at -20˚ C

IgG

CD3epsilon

CD3e Antibody [145-2C11] for use in flow cytometry, immunohistochemistry, western blotting, immunoprecipitation, blocking, depletion, CMCD, and activation assays.

Cd3e

CD3 antigen, epsilon polypeptide

Mus musculus

CD3 epsilon

WB

Liquid