CD3E (NM 000733) Humaan Recombinant eiwit

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

Purified recombinant protein of CD3-epsilon/delta heterodimers, with C-terminal His tag, secretory expressed in 293E cells, 20ug

IMD18; T3E; TCRE

916

P07766

NM_000733

11q23.3

HEK293

C-His

Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway

Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

1 x PBS, pH7.4, 10% glycerol.

Druggable Genome, Transmembrane

22.7 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

CD3E

Human

NP_000724

https://www.ncbi.nlm.nih.gov/gene/916

https://www.uniprot.org/uniprot/P07766

https://www.ncbi.nlm.nih.gov/nuccore/NM_000733

https://www.ncbi.nlm.nih.gov/nuccore/NP_000724