CD4 Antilichaam [8G1B12]

CD4 Monoclonal Antibody: CD4 is a member of the immunoglobulin superfamily and is implicated as associative recognition element in MHC (Major Histocompatibility Complex) class II-restricted immune response. On T-lymphocytes, it defines the helper/inducer subset. The mature 55 kd CD4 protein consists of a 372 amino acid extracellular segment composed of four tandem immunoglobulin-like VJ regions. The CD4 molecule is a major receptor for human immunodeficiency virus (HIV), binding directly to the envelope glycoprotein gp120 on HIV, with the co-receptors being CCR5 or CXCR4. It has been shown that the V-like domains are critical for binding with HIV envelope gp120.

920

P01730

NP_000607

Human, Mouse, Rat

PM-5203

8G1B12

Unconjugated

Primary Antibodies

Immunology

CD4 Monoclonal Antibody is Protein A purified.

Cat. No. 1462 - Rat Lung Tissue Lysate

1 mg/mL

CD4 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CD4 monoclonal antibody can be stored at -20˚ C, stable for one year.

IgG1

Human CD4 has one isoform (458aa, 51kD) . Mouse CD4 has two isoforms, including isoform 1 (457aa, 51kD) and isoform 2 (217aa, 24.5kD) . Rat CD4 has one isoform (457aa, 51kD) . PM-5203 can detect human, mouse and rat.

CD4

CD4 molecule

Homo sapiens

Bowers et al. Int. J. Biochem. Cell Biol. 1997; 29 :871-5.

Arthos et al. Cell 1989; 57:469-81.

22954649

CD4 Antibody [8G1B12] : CD4mut

ELISA, WB, IHC-P, IF

10835167

Liquid