CD4 Antilichaam [GK1.5]

CD4 is a type I transmembrane glycoprotein expressed on most thymocytes and the helper/inducer subpopulation of mature T lymphocytes of all mouse strains tested. CD4 has also been detected at low density on pluripotent hematopoietic stem cells, bone marrow myeloid precursors, and intrathymic lymphoid precursors. The CD4 antigen functions as a co-receptor, interacting with class II major histocompatability complex (MHC) molecules in the recognition of foreign antigens by T cells. In vivo and in vitro treatment with the GK1.5 monoclonal antibody effectively depletes CD4+ cells. GK1.5 also blocks helper T cell responses to MHC class II antigens, including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines.

12504

P06332

P06332

Mouse

Mouse CTL clone V4

[GK1.5]

Unconjugated

Primary Antibodies

Immunology

0.5 mg/mL

Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

None

Blue Ice

Store vial at 2-8˚ C

IgG2b

CD4

CD4 Antibody [GK1.5] for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, depletion, separation, and blocking assays.

Cd4

CD4 antigen

Mus musculus

L3T4, Ly-4

WB, ICC

Liquid