CD4 Antilichaam [OKT4]

The OKT4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV) . CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation (together with the MHC class II) . The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.

920

P01730

Human

OKT4

Unconjugated

Primary Antibodies, Functional Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Mouse IgG2b, kappa

The OKT4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV) .

CD4

CD4 molecule

Homo sapiens

Reinherz, E. L., Kung, P. C., Goldstein, G., Schlossman, S. F. (1979) . Separation of functional subsets of human T cells by a monoclonal antibody.Proceedings of the National Academy of Sciences,76 (8), 4061-4065.

Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.

Bour, S. T. E. P. H. A. N. E., Boulerice, F. R. A. N. C. O. I. S., Wainberg, M. A. (1991) . Inhibition of gp160 and CD4 maturation in U937 cells after both defective and productive infections by human immunodeficiency virus type 1.Journal of virology,65 (12), 6387-6396.

CD4mut, CD4

Flow, Functional Assays, IF, ICC, IP, WB

Liquid