CD40 Antibody - N-terminal regio : FITC (ARP41928_P050-FITC)

CD40 molecule, TNF receptor superfamily member 5

P50, Bp50, CDW40, TNFRSF5

958

P25942

NP_690593

Human, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human CD40

CD40 is the receptor for TNFSF5/CD40LG. Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3) .The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

TRAF2; TRAF3; PIK3R1; CD40LG; BAG3; Otud7b; Birc3; IL4R; TRAF6; TRAF5; TRAF3IP2; MAP3K8; TRAF4; TRAF1; PIK3CA; CBL; BIRC2; CDC40; TANK; HSPA4; NSMAF; XRCC5; HSPA8; TDP2; RIPK2; CAV1; JAK3; XRCC6; MS4A1; SUMO1; SLC30A7; RNF219; UGGT1; ERP44; NCOA6; USP15

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Guinea Pig: 91%; Horse: 83%; Human: 100%; Rabbit: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

20kDa

Hsiao, J.Y., (er) Endocr. J. (2008) In press

Wet Ice

203

CD40

CD40

Rabbit

Tumor necrosis factor receptor superfamily member 5

NM_152854

SQCCSLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCD