CD40 Antilichaam

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3) . Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

958

P25942

Human, Mouse, Rat

Recombinant protein of human CD40

Unconjugated

Primary Antibodies

Apoptosis, Cell Cycle, Immunology, Stem Cell

Affinity purification

B cells

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 42kDa

IgG

CD40

293T

SKOV3

K-562

Mouse lung

Mouse liver

CD40 molecule, TNF receptor superfamily member 5

Homo sapiens

CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50

WB, IHC, IF

Liquid