CD40 Antilichaam [5C3]

The 5C3 monoclonal antibody specifically reacts with human CD40, a 48kDA type I glycoprotein. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The 5C3 antibody partially blocks the binding of CD40L (CD154) . In the presence of IL-4 or PMA, the 5C3 antibody promotes B cell proliferation.

958

P25942

Human

5C3

Unconjugated

Primary Antibodies, Functional Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Batch dependent

Phosphate-buffered aqueous solution, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C . Do not freeze.

Mouse IgG1, kappa

The 5C3 monoclonal antibody specifically reacts with human CD40, a 48kDA type I glycoprotein.

CD40

CD40 molecule, TNF receptor superfamily member 5

Homo sapiens

Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.

Barclay, A. N., Birkeland, M. L., Brown, M. H., Beyers, A. D., David, S. J., Somoza, C., Williams, A. F. The Leukocyte Antigen Facts Book. 1993.Academic Prss, London.

Challa, A., Pound, J. D., Gordon, J., Armitage, R. J. (1999) . Epitope‐dependent synergism and antagonism between CD40 antibodies and soluble CD40 ligand for the regulation of CD23 expression and IgE synthesis in human B cells.Allergy,54 (6), 576-583.

P50, Bp50, CDW40, TNFRSF5, CD40

Flow, Functional Assays

Liquid