CD40 Antilichaam [HM40-3]

The HM40-3 monoclonal antibody reacts with mouse CD40, a 48kDA type I glycoprotein known as Bp50. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The HM40-3 antibody blocks the binding of CD40L (CD154) and stimulates B and dendritic cell proliferation.

21939

P27512

Mouse, Rat

HM40-3

Unconjugated

Primary Antibodies, Functional Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Batch dependent

Phosphate-buffered aqueous solution, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C . Do not freeze.

Armenian Hamster IgM, kappa

The HM40-3 monoclonal antibody reacts with mouse CD40, a 48kDA type I glycoprotein known as Bp50.

Cd40

CD40 antigen

Mus musculus

Kaneko, Y., Hirose, S., Abe, M., Yagita, H., Okumura, K., Shirai, T. (1996) . CD40‐mediated stimulation of B1 and B2 cells: implication in autoantibody production in murine lupus.European journal of immunology,26 (12), 3061-3065.

Ferlin, W. G., Severinson, E., Strm, L., Heath, A. W., Coffman, R. L., Ferrick, D. A., Howard, M. C. (1996) . CD40 signaling induces interleukin‐4‐independent IgE switching in vivo.European journal of immunology,26 (12), 2911-2915.

Kashiwada, M., Kaneko, Y., Yagita, H., Okumura, K., Takemori, T. (1996) . Activation of mitogen‐activated protein kinases via CD40 is distinct from that stimulated by surface IgM on B cells.European journal of immunology,26 (7), 1451-1458.

IGM, p50, Bp50, GP39, IMD3, TRAP, HIGM1, T-BAM, Tnfrsf5, AI326936, Cd40

Flow, Functional Assays

Liquid