CD40 Ligand Proteine (ECD, zijn label)

The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD154, also known as CD40 ligand or CD40L, is a member of the TNF superfamily. While CD154 was originally found on T cell surface, its expression has since been found on a wide variety of cells, including platelets, mast cells, macrophages and NK cells. CD154's ability is achieved through binding to the CD40 on antigen-presenting cells (APC) . In the macrophage cells, the primary signal for activation is IFN-γ from Th1 type CD4 T cells. The secondary signal is CD40L on the T cell, which interacting with the CD40 molecules, helping increase the level of activation.

CD154 Protein; CD40-L Protein; Cd40l Protein; Cd40lg Protein; gp39 Protein; HIGM1 Protein; IGM Protein; IMD3 Protein; Ly-62 Protein; Ly62 Protein; T-BAM Protein; Tnfsf5 Protein; Tnlg8b Protein; TRAP Protein

P27548

Mouse

Mouse

His-Tag

See Datasheet send with the product

< 1.0 EU per μg protein as determined by the LAL method.

≥ 95 % as determined by SDS-PAGE.

Immobilized Recombinant Mouse CD40 / TNFRSF5 Protein at 2μg/mL (100μL/well) can bind Recombinant Mouse CD40 Ligand Protein, the EC50 is 14-36 ng/mL.

156

Lyophilized

PBS, pH 7.4

See Datasheet

22.13 kDa and 19 kDa (glycosylated)

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

HEK 293 cells