CD41 Antilichaam [MWReg30]

The MWReg30 monoclonal antibody specifically reacts with mouse CD41, a transmembrane glycoprotein also known as integrin alpha 2b GPIIb. It is expressed on hematopoietic progenitors, megakaryocytes, and platelets. It forms a receptor with CD61 (integrin beta 3) that binds adhesion molecules such as fibrinogen, fibronectin, von Willebrand factor, and thrombin. Defects or absence of CD41 has been found to lead to coagulation disorders. The expression profile of CD150+, CD48-, and CD41- can be used to identify hematopoietic stem cells.

16399

Q9QUM0

Mouse

MWReg30

Unconjugated

Primary Antibodies

Stem Cell

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Batch dependent

Phosphate-buffered aqueous solution, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C . Do not freeze.

Rat IgG1, kappa

The MWReg30 monoclonal antibody specifically reacts with mouse CD41, a transmembrane glycoprotein also known as integrin alpha 2b GPIIb.

Itga2b

Integrin alpha 2b

Mus musculus

Schmidt, R. E., Grau, G. E., M, D. N., Nieswandt, B., Echtenacher, B., Wachs, F. P., ... Gessner, J. E. (1999) . Acute Systemic Reaction and Lung Alterations Induced by an Antiplatelet.Blood,94 (2), 684-693.

Bertrand, J. Y., Giroux, S., Golub, R., Klaine, M., Jalil, A., Boucontet, L., ... Cumano, A. (2005) . Characterization of purified intraembryonic hematopoietic stem cells as a tool to define their site of origin.Proceedings of the National Academy of Sciences of the United States of America,102 (1), 134-139.

Mitjavila-Garcia, M. T., Cailleret, M., Godin, I., Nogueira, M. M., Cohen-Solal, K., Schiavon, V., ... Vainchenker, W. (2002) . Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells.Development,129 (8), 2003-2013.

CD41, CD41B, GpIIb, AI172977, alphaIIb, Itga2b

Flow, Functional Assays

Liquid