CD46 Antilichaam

The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

4179

P15529

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 40-320 of human CD46 (NP_722548.1) .

Unconjugated

Primary Antibodies

Immunology, Innate Immunity

Affinity purification

Jurkat

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 50-56kDa

IgG

WB: 1:500 - 1:2000

CD46

Mouse testis

Rat testis

CD46 molecule, complement regulatory protein

Homo sapiens

Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, CD46, CD46, MCP, MIC10

WB

Liquid