CD48 Antilichaam [HM48-1]

The HM48-1 monoclonal antibody specifically reacts with mouse CD48, a GPI-anchored molecule in the Ig superfamily. CD48 was previously known as BCM1 in mice, Blast-1 in humans, and OX-45 in rats. Its ligands are CD2 and CD244 and it is expressed on leukocytes to the exclusion of non-hematopoietic cells. The utilization of the HM48-1 antibody has been reported to prolong cardiac allografts survival in in vivo studies. The antibody blocks the interaction of CD2 and CD244, inhibits CTL priming, and blocks the binding of soluble CD2 to CD48 expressing cells.

12506

P18181

Mouse

HM48-1

Unconjugated

Primary Antibodies

Innate Immunity, Immunology, Stem Cell

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Batch dependent

Phosphate-buffered aqueous solution, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C . Do not freeze.

Armenian Hamster IgG

The HM48-1 monoclonal antibody specifically reacts with mouse CD48, a GPI-anchored molecule in the Ig superfamily.

Cd48

CD48 antigen

Mus musculus

Kato, K., Koyanagi, M., Okada, H., Takanashi, T., Wong, Y. W., Williams, A. F., ... Yagita, H. (1992) . CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation.The Journal of experimental medicine,176 (5), 1241-1249.

Qin, L., Chavin, K. D., Lin, J., Yagita, H., Bromberg, J. S. (1994) . Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival.The Journal of experimental medicine,179 (1), 341-346.

Chavin, K. D., Qin, L., Lin, J., Woodward, J., Baliga, P., Kato, K., ... Bromberg, J. S. (1994) . Anti-CD48 (murine CD2 ligand) mAbs suppress cell mediated immunity in vivo.International immunology,6 (5), 701-709.

BCM1, BLAST, Bcm-1, BLAST1, SLAMF2, Sgp-60, BLAST-1, MEM-102, AI449234, AW610730, Cd48

Flow, Functional Assays

Liquid