CD49ab Antilichaam [HMA2]

The HMa2 monoclonal antibody specifically reacts with mouse CD49b (integrin alpha 2), a 150kDA transmembrane glycoprotein that forms the VLA-2 complex with CD29 (integrin beta 1) . VLA-2 is expressed on NK-T cells, epithelial cells, platelets, and CD+4 T lymphocytes. It is the receptor for laminin and collagen and is upregulated in response to mitogens. The Hma2 antibody is reported to partially block the interaction with collagen in T cells, but not NK cells.

16398

Q62469

Mouse

HMa2

Unconjugated

Primary Antibodies, Functional Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Batch dependent

Phosphate-buffered aqueous solution, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C . Do not freeze.

Armenian Hamster IgG

The HMa2 monoclonal antibody specifically reacts with mouse CD49b (integrin alpha 2), a 150kDA transmembrane glycoprotein that forms the VLA-2 complex with CD29 (integrin beta 1) .

Itga2

Integrin alpha 2

Mus musculus

Baron, J. L., Reich, E. P., Visintin, I., Janeway Jr, C. A. (1994) . The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1.Journal of Clinical Investigation,93 (4), 1700.

Chisholm, P. L., Williams, C. A., Lobb, R. R. (1993) . Monoclonal antibodies to the integrin alpha 4 subunit inhibit the murine contact hypersensitivity response.European journal of immunology,23 (3), 682-688.

Holzmann, B., McIntyre, B. W., Weissman, I. L. (1989) . Identification of a murine Peyer's patchspecific lymphocyte homing receptor as an integrin molecule with an alpha chain homologous to human VLA-4alpha .Cell,56 (1), 37-46.

DX5, CD49B, Itga2

Flow, Functional Assays

Liquid