CD49d Antilichaam [PS/2]

VLA-4 belongs to the beta1-integrin family, which functions both as cell-matrix and cell-cell receptors. As a matrix receptor VLA-4 binds to an alternatively spliced domain of fibronectin, while as a cellular receptor it associates with its counter-receptor ligand VCAM-1. In addition to CD44/Pgp-1, VLA-4 has been shown to be important for lymphopoiesis, and is also believed to be important for extravasation of lymphocytes into sites of inflammation as a second signal in addition to LFA/ICAM-1. CD49d is expressed in low amounts on resting lymphocytes and monocytes, is absent or minimally detectable on stromal cells, whereas virtually all lymphoid and myeloid cells in bone marrow and in long-term culture are positive. Antibody PS/2 also reacts with human VLA-4.

16401

Q00651

Q00651

Mouse, Human

P815 cells

[PS/2]

Unconjugated

Primary Antibodies

Immunology

0.5 mg/mL

Supplied in PBS

None

Dry Ice

Store vial at -20˚ C

IgG2b

CD49d

CD49d Antibody [PS/2] for use in flow cytometry, immunohistochemistry, immunoprecipitation, blocking, and adhesion assays.

Itga4

Integrin alpha 4

Mus musculus

Integrin alpha4, VLA-4alpha, ITGA4, IA4

Flow

Liquid