CD49d Antilichaam [R1-2]

The R1-2 monoclonal antibody specifically reacts with mouse CD49d (integrin alpha 4), which forms the VLA-4 complex with CD29 (integrin beta 1) . VLA-4 is expressed on thymocytes, monocytes, and a subset of peripheral lymphocytes. It is the receptor for fibronectin and CD106 (VCAM-1) . CD49d also forms a receptor for mucosal vascular addressin (MAdCAM-1) with integrin beta 7.

16401

Q00651

Mouse

R1-2

Unconjugated

Primary Antibodies, Functional Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Batch dependent

Phosphate-buffered aqueous solution, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C . Do not freeze.

Rat IgG2b, kappa

The R1-2 monoclonal antibody specifically reacts with mouse CD49d (integrin alpha 4), which forms the VLA-4 complex with CD29 (integrin beta 1) .

Itga4

Integrin alpha 4

Mus musculus

Deckert, M., Kubar, J., Zoccola, D., Bernard‐Pomier, G., Angelisova, P., Horejsi, V., Bernard, A. (1992) . CD59 molecule: a second ligand for CD2 in T cell adhesion.European journal of immunology,22 (11), 2943-2947.

Korty, P. E., Brando, C. L. A. R. A., Shevach, E. M. (1991) . CD59 functions as a signal-transducing molecule for human T cell activation.The Journal of immunology,146 (12), 4092-4098.

Davies, A., Simmons, D. L., Hale, G., Harrison, R. A., Tighe, H., Lachmann, P. J., Waldmann, H. (1989) . CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.The Journal of experimental medicine,170 (3), 637-654.

CD49D, Itga4B, Itga4

Flow, Functional Assays

Liquid