CD49f Antilichaam [4F10]

CD49f is the 125 kDa integrin alpha6 chain which associates noncovalently with the integrin beta1 subunit (CD29) and with the integrin beta4 (CD104) chain to form, respectively, the very late antigen-6 (VLA-6) and alpha6beta4 integrin heterodimers. VLA-6 is expressed on thymocytes, T lymphocytes, monocytes, and platelets. CD49f/CD29 expression is upregulated on activated T lymphocytes and memory T cells. VLA-6 serves as the laminin receptor on platelets, monocytes, and T cells. VLA-6-mediated binding to laminin provides a costimulatory signal to T cells for activation and proliferation.

3655

P23229

P23229

Human

SW1222 human colorectal cell line

[4F10]

Unconjugated

Primary Antibodies

Cell Cycle, Signal Transduction

0.1 mg/mL

Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

None

Blue Ice

Store vial at 2-8˚ C

IgG2b

CD49f

CD49f Antibody [4F10] for use in flow cytometry, immunohistochemistry, and immunoprecipitation assays.

ITGA6

Integrin alpha-6

Homo sapiens

Integrin alpha6 chain, VLA-6 alpha chain, platelet gpIc

IHC-Fr, Flow

Liquid