CD51/CD61 Antilichaam [23C6]

The 23C6 monoclonal antibody specifically reacts with the human CD51/61 molecule, known as the integrin alpha v Beta 3 complex or vitronectin receptor. The complex binds to other ligands such as CD29, fibrinogen, fibrinectin, vWf, laminin, and thrombospondin. It is expressed by endothelial cells, osteoclasts, melanoma cells, and at low levels on platelets and macrophages. The 23C6 antibody is reported to be able to block the receptors ability to form interactions with some of its ligands.

3685;3690

P06756; P05106

Human

23C6

Unconjugated

Primary Antibodies, Functional Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Batch dependent

Phosphate-buffered aqueous solution, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C . Do not freeze.

Mouse IgG1, kappa

The 23C6 monoclonal antibody specifically reacts with the human CD51/61 molecule, known as the integrin alpha v Beta 3 complex or vitronectin receptor.

ITGAV; ITGB3

Integrin, alpha V; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

Homo sapiens

Horton, M. A., Lewis, D., McNulty, K., Pringle, J. A., Chambers, T. J. (1985) . Monoclonal antibodies to osteoclastomas (giant cell bone tumors) : definition of osteoclast-specific cellular antigens.Cancer research,45 (11 Part 2), 5663-5669.

Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.

Chuntharapai, A., Bodary, S., Horton, M., Kim, K. J. (1993) . Blocking monoclonal antibodies to alpha v-beta 3 integrin: A unique epitope of alpha v-beta 3 integrin is present on human osteoclasts.Experimental cell research,205 (2), 345-352.

CD51, MSK8, VNRA, VTNR, GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16, ITGAV, ITGB3

Flow, Functional Assays

Liquid