CD54 Antilichaam [15.2] (PE)

The 15.2 antibody reacts with human CD54, also known as ICAM-1 (Intercellular Adhesion Molecule 1), a 90-110 kDa cell surface glycoprotein that is inducibly expressed on both immune and endothelial cells. As its name implies, ICAM-1 participates in cell-cell adhesion between leukocytes and endothelial cells, facilitating leukocyte recruitment and transmigration at sites of inflammation. The ligands for ICAM-1 are also expressed on leukocyte and endothelial cells, and include Mac-1, fibrinogen, and a member of the integrin protein family, LFA-1 (CD11a) .The 15.2 antibody may be used for analysis of ICAM-1 expression in human cells and tissues, and is reported to be cross-reactive with porcine ICAM-1.

3383

P05362

Human

15.2

PE

Primary Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Mouse IgG1

The 15.2 antibody reacts with the 85-110 kDa intracellular adhesion molecule-1 (ICAM-1), a member of the Ig superfamily which acts as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1) .

ICAM1

Intercellular adhesion molecule 1

Homo sapiens

Bhattacharya, A. L. O. K., Dorf, M. E., Springer, T. A. (1981) . A shared alloantigenic determinant on Ia antigens encoded by the IA and IE subregions: evidence for I region gene duplication. The Journal of Immunology,127 (6), 2488-2495.

Mendiratta, S. K., Singh, N., Bal, V., Rath, S. (1996) . Analysis of T-cell hybridomas with an unusual MHC class II-dependent ligand specificity.Immunology,89 (2), 238-244.

Unternaehrer, J. J., Chow, A., Pypaert, M., Inaba, K., Mellman, I. (2007) . The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface.Proceedings of the National Academy of Sciences,104 (1), 234-239.

BB2, CD54, P3.58, ICAM1

Flow

Liquid