CD54 Antilichaam [YN1/1.7.4] (FITC)

CD54, a member of the immunoglobulin superfamily of cell surface receptors and also known as Intercellular Adhesion Molecule-1 (ICAM-1), is a type I transmembrane glycoprotein that mediates important cell/cell interactions. CD54 is expressed on endothelial cells, dendritic cells, keratinocytes, and lymphocytes. Its expression is upregulated by inflammatory mediators such as IFN gamma, IL-1, TNF-alpha, lipopolysaccharide, and phorbol esters. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels, particularly in areas of inflammation. CD54 on antigen-presenting cells contributes to antigen-specific T-cell activation, presumably by enhancing interactions between T cell and antigen-presenting cells. These adhesion reactions are mediated via the binding of CD54 to its major ligands, LFA-1 and Mac-1.

15894

P13597

P13597

Mouse, Pig

Mouse NS-1 cells

[YN1/1.7.4]

FITC

Primary Antibodies

Immunology, Signal Transduction

0.5 mg/mL

Supplied in PBS/NaN3

None

Blue Ice

Store vial at 2-8˚ C

IgG2b

CD54

CD54 Antibody [YN1/1.7.4] for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.

Icam1

Intercellular adhesion molecule 1

Mus musculus

ICAM-1, Ly-47

Flow

Liquid