CD59 Mouse Monoclonal Antibody [Kloon ID: LBI2E11]

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Carrier-free (glycerol/BSA-free) CD59 mouse monoclonal antibody, clone LBI2E11

1F5; 16.3A5; EJ16; EJ30; EL32; G344; HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2

Homo sapiens CD59 molecule (CD59 blood group) (CD59), transcript variant 2, mRNA.

966

P13987

Unconjugated

Complement and coagulation cascades, Hematopoietic cell lineage

Complement and coagulation cascades, Hematopoietic cell lineage

WB 1:4000

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

CD59

https://www.ncbi.nlm.nih.gov/gene/?term=966

https://www.uniprot.org/uniprot/P13987