CD62E/CD62P Antilichaam [1,2B6]

CD62E represents the 97 kDa type I transmembrane glycoprotein E-selectin, also known as endothelial-leukocyte adhesion molecule-1 (ELAM-1) . It is expressed on cytokine-stimulated endothelium, weakly on unactivated endothelium, and is absent on leukocytes. Like other selectins, CD62E is an adhesion molecule that contributes to the initial attachment and rolling of leukocytes on endothelial surfaces, a prerequisite for leukocyte extravasation into tissues. CD62P is a 140 kDa membrane glycoprotein formerly known as platelet activation-dependent granule membrane protein (PADGEM) or GMP-140. It is expressed on platelets, megakaryocytes, and epithelium. It is thought to mediate the adhesive interactions of neutrophils and monocytes with endothelium in inflammatory responses and of activated platelets to neutrophils and monocytes in hemostasis. The monoclonal antibody 1.2B6 recognizes a common epitope shared by CD62E and CD62P.

6401

P16581

P16581

Human, Pig

TNF stimulated human endothelial cells

[1.2B6]

Unconjugated

Primary Antibodies

Immunology, Signal Transduction

0.1 mg/mL

Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

None

Blue Ice

Store vial at 2-8˚ C

IgG1

CD62E/CD62P

CD62E/CD62P Antibody [1.2B6] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, ELISA, adhesion, and blocking assays.

SELE

E-selectin

Homo sapiens

E-selectin, P-selectin, ELAM-1, LECAM-2, PADGEM, GMP-140, LECAM-3

Flow

Liquid