CD62L Antilichaam [MEL-14]

CD62L, also known as L-selectin, is a type I transmembrane glycoprotein with lectin-like and epidermal growth factor-like domains. It binds to sialylated oligosaccharide determinants on high endothelial venules (HEV) in peripheral lymph nodes. In the mouse, CD62L is expressed on most thymocytes and on peripheral leukocytes, including B and T lymphocytes, neutrophils, monocytes, and eosinophils. This member of the selectin family of cell adhesion molecules appears to be required for lymphocyte homing to peripheral lymph nodes and for leukocyte extravasation at sites of inflammation. Expression of CD62L on lymphocytes and neutrophils is rapidly down-regulated upon cell activation and the level of CD62L expression, along with other markers, distinguishes naive T cells from effector/memory T cells. The monoclonal antibody MEL-14 blocks in vitro binding of lymphocytes to peripheral lymph node HEV and inhibits in vivo lymphocyte extravasation into peripheral lymph nodes and the late stages of leukocyte rolling.

20343

P18337

P18337

Mouse

C3H/eb cloned mouse B cell lymphoma 38C-13

[MEL-14]

Unconjugated

Primary Antibodies

Immunology

0.5 mg/mL

Supplied in PBS

None

Dry Ice

Store vial at -20˚ C

IgG2a

CD62L

CD62L Antibody [MEL-14] for use in flow cytometry, immunohistochemistry, immunoprecipitation, blocking, and cytotoxicity assays.

Sell

Selectin, lymphocyte

Mus musculus

L-selectin, LECAM-1, LAM-1, Ly-22, Sell, Lnhr, Lyam-1

Flow

Liquid