CD62P Antilichaam [Psel.KO2.3] (PE)

The Psel.KO2.3 monoclonal antibody specifically reacts with mouse CD62P (P-Selectin), a 140 kDA type I transmembrane glycoprotein also known as granule membrane protein 140 (GMP-140) . Upon activation it is quickly transported to the plasma membrane from the alpha-granules of platelets and WEibel-Palade bodies of endothelial cells. It is essential to the functions of cell adhesion during inflammatory reactions and in the interaction of platelets with monocytes and neutrophils. The Psel.KO2.3 antibody does not block adhesion and binds to an epitope common to several species including mouse, human, and rat.

6403;20344

P16109; P18337

Human, Mouse

Psel.KO2.3

PE

Primary Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Mouse IgG1, kappa

The Psel.KO2.3 monoclonal antibody specifically reacts with mouse CD62P (P-Selectin), a 140 kDA type I transmembrane glycoprotein also known as granule membrane protein 140 (GMP-140) .

SELP

Selectin P (granule membrane protein 140kDa, antigen CD62)

Homo sapiens; Mus musculus

Massaguer, A., Engel, P., Prez‐del‐Pulgar, S., Bosch, J., Pizcueta, P. (2000) . Production and characterization of monoclonal antibodies against conserved epitopes of P‐selectin (CD62P) .Tissue antigens,56 (2), 117-128.

Kansas, G. S. (1996) . Selectins and their ligands: current concepts and controversies.Blood,88 (9), 3259-3287.

Bullard, D. C., Kunkel, E. J., Kubo, H., Hicks, M. J., Lorenzo, I., Doyle, N. A., ... Beaudet, A. L. (1996) . Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice.The Journal of experimental medicine,183 (5), 2329-2336.

CD62, GRMP, PSEL, CD62P, GMP140, LECAM3, PADGEM, Lnhr, CD62L, Ly-22, Lyam1, Ly-m22, Lyam-1, LECAM-1, AI528707, L-selectin, SELP

Flow

Liquid