CD71 Antilichaam [RI7217]

CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the transferrin receptor. It is essential for the growth of normal and neoplastic cells. It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens presumably reflecting the iron dependence of proliferation. Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron which is essential for many metabolic pathways through the binding and endocytosis of transferrin, the major iron-carrying protein. It may also be involved in signal transduction via its association with the T cell receptor ζ chain. The monoclonal antibody RI7217 inhibits cell proliferation in vitro.

22042

Q62351

Q62351

Mouse

DMSO induced Friend erythroleukemia 745.6

[RI7217]

Unconjugated

Primary Antibodies

Cancer, Immunology, Obesity, Signal Transduction

0.5 mg/mL

Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

None

Blue Ice

Store vial at 2-8˚ C

IgG2a

CD71

CD71 Antibody [RI7217] for use in flow cytometry, immunocytochemistry, western blotting, immunoprecipitation, blocking, separation, and drug delivery assays.

Tfrc

Transferrin receptor

Mus musculus

T9, transferrin receptor, TfR

Flow

Liquid