CD80 Antilichaam [3H5] (PE)

The 3H5 monoclonal antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR) . CD28 also binds a second B7 ligand known as CD86 (B7-2) . Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. The 3H5 antibody blocks the binding of CD80 to its ligands.

25408

Rat

3H5

PE

Primary Antibodies

Innate Immunity, Immunology

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Mouse IgG1, kappa

The 3H5 monoclonal antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR) .

Cd80

Cd80 molecule

Rattus norvegicus

Damoiseaux, J. G., Yagita, H., Okumura, K., van Breda Vriesman, P. J. (1998) . Costimulatory molecules CD80 and CD86 in the rat

Maeda, K., Sato, T., Azuma, M., Yagita, H., Okumura, K. (1997) . Characterization of rat CD80 and CD86 by molecular cloning and mAb.International immunology,9 (7), 993-1000.

Bluestone, J. A. (1995) . New perspectives of CD28-B7-mediated T cell costimulation.Immunity,2 (6), 555-559.

B7-1, Cd80

Flow

Liquid