CD86 Antilichaam [PO3.1] (PE)

The PO3.1 monoclonal antibody specifically reacts with CD86, also known as B7-2, a surface 80 kDa receptor and member of the B7 family. CD86 is a costimulatory molecule, expressed on B and T cells, dendritic cells, astrocytes, macrophages, Langerhans cells, and at a low level in newly explanted B and T lymphocytes. CD86 expression on B lymphocytes is upregulated by B-Cell Receptor complex, CD40 and certain cytokine receptors. CD80 (B7-1) and CD 86 (B7-2) are receptors for CD28 and CTLA-4, on the surface of T lymphocytes, enhancing the interactions between B and T cells.

12524

P42082

Mouse

PO3.1

PE

Primary Antibodies

Innate Immunity

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Rat IgG2b, kappa

The PO3.1 monoclonal antibody specifically reacts with CD86, also known as B7-2, a surface 80 kDa receptor and member of the B7 family.

Cd86

CD86 antigen

Mus musculus

McMichael, A. J. (1987) .Leucocyte typing III: white cell differentiation antigens. Oxford University Press, USA.

Lankester, A. C., van Schijndel, G. M., Cordell, J. L., van Noesel, C. J., van Lier, R. A. (1994) . CD5 is associated with the human B cell antigen receptor complex.European journal of immunology,24 (4), 812-816.

Kap, Y. S., van Meurs, M., van Driel, N., Koopman, G., Melief, M. J., Brok, H. P., ... A't Hart, B. (2009) . A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates.Journal of Histochemistry Cytochemistry,57 (12), 1159-1167.

B7, B70, MB7, B7-2, B7.2, CLS1, Ly58, ETC-1, Ly-58, MB7-2, Cd28l2, TS/A-2, Cd86

Flow

Liquid