CD8a Antilichaam [2,43] (APC)

The 2.43 monoclonal antibody specifically reacts with mouse CD8 antigen. CD8a (the alpha chains) form heterodimers with CD8b (the beta chains) or homodimers (alpha-alpha), which occur as receptors on the surface of the majority of thymocytes. A subpopulation of mature T lymphocytes expresses the CD8 alpha beta (alpha beta TCR T cells), and a subpopulation of intestinal intraepithelial lymphocytes and dendritic cells express CD8a without CD8b. CD8 interacts with the mouse major histocompatibility complex class I (MHC class I) molecules on antigen-presenting cells or epithelial cells.

12525

P01731

Mouse

2.43

APC

Primary Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Rat IgG2b

The 2.43 monoclonal antibody specifically reacts with mouse CD8 antigen.

Cd8a

CD8 antigen, alpha chain

Mus musculus

Hirji, N., Lin, T. J., Bissonnette, E., Belosevic, M., Befus, A. D. (1998) . Mechanisms of macrophage stimulation through CD8: macrophage CD8alpha and CD8-beta induce nitric oxide production and associated killing of the parasite Leishmania major.The Journal of Immunology,160 (12), 6004-6011.

Hirji, N., Lin, T. J., Befus, A. D. (1997) . A novel CD8 molecule expressed by alveolar and peritoneal macrophages stimulates nitric oxide production.The Journal of Immunology,158 (4), 1833-1840.

Torres‐Nagel, N., Kraus, E., Brown, M. H., Tiefenthaler, G., Mitnacht, R., Williams, A. F., Hnig, T. (1992) . Differential thymus dependence of rat CD8 isoform expression.European journal of immunology,22 (11), 2841-2848.

Ly-2, Ly-B, Ly-35, Lyt-2, BB154331, Cd8a

Flow

Liquid