CD8a Antilichaam [2,43] (APC)

The 2.43 monoclonal antibody specifically reacts with mouse CD8 antigen. CD8a (the alpha chains) form heterodimers with CD8b (the beta chains) or homodimers (alpha-alpha), which occur as receptors on the surface of the majority of thymocytes. A subpopulation of mature T lymphocytes expresses the CD8 alpha beta (alpha beta TCR T cells), and a subpopulation of intestinal intraepithelial lymphocytes and dendritic cells express CD8a without CD8b. CD8 interacts with the mouse major histocompatibility complex class I (MHC class I) molecules on antigen-presenting cells or epithelial cells.

12525

P01731

Mouse

2.43

APC

Primary Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Rat IgG2b

The 2.43 monoclonal antibody specifically reacts with mouse CD8 antigen.

Cd8a

CD8 antigen, alpha chain

Mus musculus

Sayos, J., Wu, C., Morra, M., Wang, N., Zhang, X., Allen, D., ... Terhorst, C. (1998) . The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM.Nature,395 (6701), 462-469.

Thomas, Y., Sosman, J., Irigoyen, O., Friedman, S. M., Kung, P. C., Goldstein, G., Chess, L. (1980) . Functional analysis of human T cell subsets defined by monoclonal antibodies. I. Collaborative TT interactions in the immunoregulation of B cell differentiation.The Journal of Immunology,125 (6), 2402-2408.

Campanelli, R., Palermo, B., Garbelli, S., Mantovani, S., Lucchi, P., Necker, A., ... Giachino, C. (2002) . Human CD8 coreceptor is strictly involved in MHCpeptide tetramerTCR binding and T cell activation.International immunology,14 (1), 39-44.

Ly-2, Ly-B, Ly-35, Lyt-2, BB154331, Cd8a

Flow

Liquid