CD8a Antilichaam [CT-8] (APC)

In the chicken, the CD8 molecule is present in two forms - (i) a homodimer of two alpha chains and (ii) a heterodimer of an alpha chain and a beta chain. While the vast majority of CD8+ cells in the thymus, spleen, and blood of adult chickens express both CD8alpha- and CD8beta-chains, a relatively large proportion of the CD8+ TCRgammadelta cells in the spleens of embryos and young chicks express only the alpha-chain of CD8. Among intestinal epithelial lymphocytes, the major CD8+ T cell populations present in mice are conserved but there is a population of TCRgammadelta CD8alphabeta cells in the chicken that is not found in rodents. Chicken CD8 is expressed on approximately 80% of thymocytes, 15% of blood mononuclear cells, and 50% of spleen cells but less than 1% of cells in the bursa and bone marrow. The monoclonal antibody CT-8 recognizes the CD8alpha chain and has been shown to react to a polymorphic determinant in turkey.

403158

Chicken, Turkey, Guinea Fowl, Pigeon

Chicken thymocytes and Ig-negative blood leukocytes

[CT-8]

APC

Primary Antibodies

Cancer, Immunology, Signal Transduction

0.1 mg/mL

Supplied in PBS/NaN3 and a stabilizing agent

None

Blue Ice

Store vial at 2-8˚ C

IgG1

CD8alpha

CD8a Antibody [CT-8] for use in flow cytometry assays.

CD8A

CD8a molecule

Gallus gallus

Flow

Liquid