CD95 Antilichaam [DX2]

CD95, also known as Fas and APO-1, is a 45 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts, and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance. Crosslinking of CD95 by the monoclonal antibodies DX2 and DX3 delivers an apoptotic signal to Fas-sensitive cells indicating that these monoclonal antibodies recognize a functional epitope of CD95.

355

P25445

P25445

Human, Rhesus Monkey, African Green Monkey, Sooty Mangabey

Human CD95 transfected L cells

[DX2]

Unconjugated

Primary Antibodies

Cancer, Cell Cycle, Immunology, Signal Transduction

0.1 mg/mL

Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

None

Blue Ice

Store vial at 2-8˚ C

IgG1

CD95

CD95 Antibody [DX2] for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, ELISA, and apoptosis assays.

FAS

Tumor necrosis factor receptor superfamily member 6

Homo sapiens

APO-1, Fas, TNFRSF6

Flow, IP

Liquid