CD95 Antilichaam [EOS9.1]

The EOS9.1 monoclonal antibody specifically reacts with human CD95, a 45 kDA type I membrane molecule. CD95 is a member of the tumor necrosis factor receptor (TNF-R) family and is involved in the mechanisms that lead to cellular apoptosis. It is expressed on fibroblasts, monocytes, lymphocytes, and neutrophils. CD95 induces apoptosis after binding with CD178 or Fas ligand and the EOS9.1 antibody is reported to be used for inducing apoptosis in Fas-positive cells.

355

P25445

Human

EOS9.1

Unconjugated

Primary Antibodies, Functional Antibodies

Other

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Batch dependent

Phosphate-buffered aqueous solution, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C . Do not freeze.

Mouse IgM, kappa

The EOS9.1 monoclonal antibody specifically reacts with human CD95, a 45 kDA type I membrane molecule. CD95 is a member of the tumor necrosis factor receptor (TNF-R) family and is involved in the mechanisms that lead to cellular apoptosis.

FAS

Fas cell surface death receptor

Homo sapiens

Deaglio, S., Zubiaur, M., Gregorini, A., Bottarel, F., Ausiello, C. M., Dianzani, U., ... Malavasi, F. (2002) . Human CD38 and CD16 are functionally dependent and physically associated in natural killer cells.Blood,99 (7), 2490-2498.

Peruzzi, G., Femnou, L., Gil-Krzewska, A., Borrego, F., Weck, J., Krzewski, K., Coligan, J. E. (2013) . Membrane-type 6 matrix metalloproteinase regulates the activation-induced downmodulation of CD16 in human primary NK cells.The Journal of Immunology,191 (4), 1883-1894.

Wirthmueller, U., Kurosaki, T., Murakami, M. S., Ravetch, J. V. (1992) . Signal transduction by Fc gamma RIII (CD16) is mediated through the gamma chain.The Journal of experimental medicine,175 (5), 1381-1390.

APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6, FAS

Flow, Functional Assays

Liquid