Cdc14A Polyklonale Antilichaam, PE Vervoeging

In budding yeast, the Cdc14a phosphatase activates mitotic exit by dephosphorylation of specific cyclin-dependent kinase (Cdk) substrates and seems to be regulated by sequestration in the nucleolus until its release during mitosis. Human Cdc14a phosphatase is highly similar to Saccharomyces cerevisiae Cdc14 and is a member of the dual specificity protein Tyrosine phosphatase family. It interacts with and dephosphorylates tumor suppressor protein p53 and may regulate the function of p53. In addition, Cdc14a dephosphorylates hCdh1 and activates APCCdh1. Cdc14a phosphatase plays a role in the regulation of the centrosome cycle, mitosis and cytokinesis, thereby influencing chromosome partitioning and genomic stability in human cells. Deregulated human Cdc14a phosphatase disrupts centrosome separation and chromosome segregation.

CDC 10; Cdc 14; Cdc 14A; Cdc 14A1; Cdc 14A2; CDC10; Cdc14; CDC14 cell division cycle 14 homolog A; CDC14 homolog A; Cdc14A1; Cdc14A2; Cell division cycle 14 homolog A; Dual specicity protein phosphatase CDC 14A; Dual specicity protein phosphatase CDC14A; hCDC14; CC14A_HUMAN.

8556

Q9UNH5

Cytoplasm, Nucleus

Human, Mouse

51-150/594

Cdc14A

PE

KLH conjugated synthetic peptide derived from human Cdc14A

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

496,564nm/578nm

1µg/µl

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

8556

Rat, Dog, Cow, Sheep, Horse