CDC25B (fosfo Ser353) Antilichaam

Cdc25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.

994

P30305

NP_001274445.1

Human

CDC25B (phospho Ser353) antibody was raised against a peptide sequence around phosphorylation site of serine 353 (R-R-S (p) -V-T) derived from Human CDC25B .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

64 kDa

IgG

The antibody detects endogenous level of CDC25B only when phosphorylated at serine 353.

Western Blot: 1:500~1:1000

CDC25B

Cell division cycle 25B

Homo sapiens

Reboutier D, et al. (2012) J Cell Biol 197, 19-26

Lobjois V, et al. (2011) Biochem Biophys Res Commun 410, 87-90

Feng C, et al. (2007) Biol Reprod 77, 560-8

CDC25M2, MPIP2, Dual specificity phosphatase Cdc25B, CDC25HU2

WB

11641413

Liquid