CDC25C (fosfo Ser198) Antilichaam

Cdc25C is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.

995

P30307

NP_001274511.1

Human

CDC25C (phospho Ser198) antibody was raised against a peptide sequence around phosphorylation site of Serine 198 (E-F-S (p) -L-K) derived from Human CDC25C.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

53 kDa

IgG

The antibody detects endogenous levels of CDC25C only when phosphorylated at serine 198.

CDC25C

Cell division cycle 25C

Homo sapiens

Sadhu K., Proc. Natl. Acad. Sci. U.S.A. 87:5139-5143 (1990) .

Bureik M., Int. J. Oncol. 17:1251-1258 (2000) .

Wegener S., Eur. J. Cell Biol. 79:810-815 (2000) .

CDC25M1, MPI1B, MPIP3, EC 3.1.3.48

IHC

12408658

Liquid