CDC27 Antilichaam - middengebied HRP (ARP43603 P050-HRP)

Cell division cycle 27 homolog (S. cerevisiae)

APC3, HNUC, NUC2, H-NUC, ANAPC3, CDC27Hs, D0S1430E, D17S978E

996

P30260

NP_001247

Human, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human CDC27

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

ANAPC2; UBE2S; PTTG1; FBXO43; MAD2L1; COMT; CDC20; CCNB1; BUB1B; UBC; BIRC6; ANAPC4; CDH1; FZR1; MIB1; HECW2; ANAPC11; PHF8; CUEDC2; Sirt2; Dlg4; GKN1; ANAPC7; ANAPC5; DCPS; ADNP; MDC1; PTEN; TRIM33; REV1; ANAPC15; VCP; MAD2L2; NOTCH1; PAXIP1; UBE4B; TTK

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

CDC27 is strongly supported by BioGPS gene expression data to be expressed in NCI-H226

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Rabbit: 100%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

92kDa

Wet Ice

824

CDC27

CDC27

Rabbit

Cell division cycle protein 27 homolog

NM_001256

KLKMKFPPKIPNRKTKSKTNKGGITQPNINDSLEITKLDSSIISEGKIST