CDH4 Antilichaam

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene.

1002

P55283

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 757-916 of human CDH4 (NP_001785.2) .

Unconjugated

Primary Antibodies

Cell Cycle, Neuroscience, Signal Transduction

Affinity purification

HepG2

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 100kDa/115kDa

IgG

WB: 1:1000 - 1:2000

CDH4

Mouse brain

Mouse thymus

Rat brain

Rat skeletal muscle

Cadherin 4, type 1, R-cadherin (retinal)

Homo sapiens

CDH4, CAD4, FLJ22202, FLJ40547, MGC126700, MGC138355, RCAD

WB

Liquid