CDIP-antilichaam

CDIP Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.

29965

Q9H305

NP_037531

Human, Mouse

Unconjugated

Primary Antibodies

Apoptosis

CDIP Antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (100%), Bovine: (100%)

CDIP Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CDIP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

CDIP1

Cell death inducing p53 target 1

Homo sapiens

Guimaraes DP and Hainaut P. TP53: a key gene in human cancer. Biochimie2002; 84:83-93.

Brown L, Ongusaha PP, Kim H-H, et al. CDIP, a novel pro-apoptotic gene, regulates TNFa-mediated apoptosis in a p53-dependent manner. EMBO J.2007; 26:3410-22.

CDIP Antibody: I1, CDIP, LITAFL, C16orf5, Cell death-inducing p53-target protein 1, Cell death involved p53-target

ELISA, WB, IHC-P, IF

118344450

Liquid